Article
In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Nov 2005
Lin Jui-Ming, Schroeder Analyne, Allada Ravi
Abstract excerpt
Phosphorylation plays a key role in the precise timing of circadian clocks. Daily rhythms of phosphorylation of the Drosophila circadian clock component PERIOD (PER) were first described more than a decade ago, yet little is known about their phosphorylation sites and their function in circadian behavior. Here we show that serines 151 and 153 in PER are required for robust in vitro phosphorylation by the casein...
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