Article
Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.
Neuron - 10 Apr 2008
Meng Qing-Jun, Logunova Larisa, Maywood Elizabeth S, Gallego Monica, Lebiecki Jake, Brown Timothy M, Sládek Martin, Semikhodskii Andrei S, Glossop Nicholas R J, Piggins Hugh D, Chesham Johanna E, Bechtold David A, Yoo Seung-Hee, Takahashi Joseph S, Virshup David M, Boot-Handford Raymond P, Hastings Michael H, Loudon Andrew S I
Abstract excerpt
The intrinsic period of circadian clocks is their defining adaptive property. To identify the biochemical mechanisms whereby casein kinase1 (CK1) determines circadian period in mammals, we created mouse null and tau mutants of Ck1 epsilon. Circadian period lengthened in CK1epsilon-/-, whereas CK1...
Topics
- Animals
- Biological Clocks
- Casein Kinase 1 epsilon
- Cell Line
- Cells, Cultured
- Circadian Rhythm
- Humans
- Mice
- Mice, Knockout
- Mice, Transgenic