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Article

Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.

PLoS genetics - 1 Jan 2008

Smith Elaine M, Lin Jui-Ming, Meissner Rose-Anne, Allada Ravi

Abstract excerpt

Circadian clocks organize the precise timing of cellular and behavioral events. In Drosophila, circadian clocks consist of negative feedback loops in which the clock component PERIOD (PER) represses its own transcription. PER phosphorylation is a critical step in timing the onset and termination of this feedback. The protein kinase CK2 has been linked to circadian timing, but the importance of this contribution...

Topics

Alleles
Animals
Animals, Genetically Modified
Casein Kinase II
Circadian Rhythm
Drosophila
Feedback, Physiological
Genes, Dominant
Immunohistochemistry
Insect Proteins
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation, Missense

Neurons

Phosphorylation

Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 18208335
DOI: 10.1371/journal.pgen.0040012
PMCID: PMC2211540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18208335-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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