Article
Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2020
Masuda Shusaku, Narasimamurthy Rajesh, Yoshitane Hikari, Kim Jae Kyoung, Fukada Yoshitaka, Virshup David M
Abstract excerpt
Casein kinase 1 (CK1) plays a central role in regulating the period of the circadian clock. In mammals, PER2 protein abundance is regulated by CK1-mediated phosphorylation and proteasomal degradation. On the other hand, recent studies have questioned whether the degradation of the core circadian machinery is a critical step in clock regulation. Prior cell-based studies found that CK1 phosphorylation of PER2 at...
Topics
- Animals
- Behavior, Animal
- Casein Kinase I
- Cell Nucleus
- Circadian Clocks
- Circadian Rhythm
- Female
- Gene Expression Regulation
- Liver
- Male
- Mice