Article
Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2020
Masuda Shusaku, Narasimamurthy Rajesh, Yoshitane Hikari, Kim Jae Kyoung, Fukada Yoshitaka, Virshup David M
Abstract excerpt
Casein kinase 1 (CK1) plays a central role in regulating the period of the circadian clock. In mammals, PER2 protein abundance is regulated by CK1-mediated phosphorylation and proteasomal degradation. On the other hand, recent studies have questioned whether the degradation of the core circadian machinery is a critical step in clock regulation. Prior cell-based studies found that CK1 phosphorylation of PER2 at...
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