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Article

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2009

Lee Hyeongmin, Chen Rongmin, Lee Yongjin, Yoo Seunghee, Lee Choogon

Abstract excerpt

Circadian rhythms in mammals are generated by a negative transcriptional feedback loop in which PERIOD (PER) is rate-limiting for feedback inhibition. Casein kinases Idelta and Iepsilon (CKIdelta/epsilon) can regulate temporal abundance/activity of PER by phosphorylation-mediated degradation and cellular localization. Despite their potentially crucial effects on PER, it has not been demonstrated in a mammalian...

Topics

Animals
Casein Kinase 1 epsilon
Casein Kinase Idelta
Cell Line
Circadian Rhythm
Drosophila
Fibroblasts
Mice
Mice, Knockout
Mutation
Period Circadian Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 19948962
DOI: 10.1073/pnas.0906651106
PMCID: PMC2795500

Genes

DBT
PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19948962-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.PMID 19948962Read ↗

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