Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.

doi:10.1126/scisignal.2000305

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Article

Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.

Science signaling - 2 Jun 2009

Tsuchiya Yoshiki, Akashi Makoto, Matsuda Mitsuhiro, Goto Kyoko, Miyata Yoshihiko, Node Koichi, Nishida Eisuke

Abstract excerpt

Posttranslational modifications of clock proteins are crucial to generating proper circadian rhythms of the correct length and amplitude. Here, we show that the protein kinase CK2 (casein kinase 2) plays a role in regulating the mammalian circadian clock. We found that inhibiting CK2 activity res...

Topics

Animals
Binding Sites
Casein Kinase II
Circadian Rhythm
Gene Expression
Humans
Mutation
Nuclear Proteins
Period Circadian Proteins
Phosphorylation
Substrate Specificity
Transcription Factors

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