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Article

The kinetics of ER fusion protein activation in vivo

24 Mar 2014

Abstract excerpt

Reversibly switchable proteins are powerful tools with which to explore protein function in vitro and in vivo. For example, the activity of many proteins fused to the hormone-binding domain of the modified oestrogen receptor (ER(TAM)) can be regulated by provision or removal of 4-hydroxytamoxifen (4-OHT). Despite the widespread use of ER(TAM) fusions in vivo, inadequate data are available as to the most...

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PMID: 24662815
DOI: 10.1038/onc.2014.78

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