Article
Site- and time-specific gene targeting in the mouse.
Methods (San Diego, Calif.) - 1 May 2001
Metzger D, Chambon P
Abstract excerpt
The efficient introduction of somatic mutations in a given gene, at a given time, in a specific cell type, will facilitate studies of gene function and the generation of animal models for human diseases. We have established a conditional site-specific recombination system in mice using a new version of the Cre/lox system. The Cre recombinase has been fused to a mutated ligand binding domain of the human estrogen...
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