Article
Fusion estrogen receptor proteins: toward the development of receptor-based agonists and antagonists.
Molecular and cellular endocrinology - 1 Sept 2001
Muyan M, Yi P, Sathya G, Willmert L J, Driscoll M D, Hilf R, Bambara R A
Abstract excerpt
Estrogen-induced signaling mediated by estrogen receptors (ERs) is also affected by aberrant ERs that act as constitutively active or dominant negative modulators. Variant ERs can contribute to carcinogenesis and to the loss of estrogen responsiveness, rendering antiestrogen therapy ineffective. Determining target gene response during co-synthesis of different ER species is difficult, because dimers formed in the...
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