Pharmacologically regulated bioorthogonal stabilization domain for regulation of CAR T cells

Abstract excerpt

Regulation of therapeutic cell response is important for safe and effective therapy, particularly for immunotherapy. Ideally, the regulators should be based on human proteins using compounds that have already been approved for human use. Regulation of protein degradation by small molecules enables fast cellular response and a small genetic footprint of genetic constructs. Here, we present a clinically compatible s...

Topics

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• Biosimilars and Bioanalytical Methods
• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Nanowire Synthesis and Applications
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

f0f12533-f2a0-5840-acd3-3cf8d6e1884e

DOI

10.64898/2026.07.15.738628