Article
Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 1998
Logie C, Nichols M, Myles K, Funder J W, Stewart A F
Abstract excerpt
Activation of the estrogen receptor (ER) by hormone involves at least two steps. First, hormone binding initially relieves repression, a property imposed on ER in cis by its ligand-binding domain (EBD). Subsequently, the derepressed ER binds specific genomic sites and regulates transcription. In...
Topics
- DNA Nucleotidyltransferases
- Diethylstilbestrol
- Dimerization
- Estradiol
- Estrogen Antagonists
- Fulvestrant
- Hexestrol
- Humans
- Mutation
- Piperidines
- Raloxifene Hydrochloride
- Receptors, Estrogen
- Recombinant Fusion Proteins
- Tamoxifen