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Article

Destabilizing domains derived from the human estrogen receptor.

Journal of the American Chemical Society - 7 Mar 2012

Miyazaki Yusuke, Imoto Hiroshi, Chen Ling-chun, Wandless Thomas J

Abstract excerpt

Methods to rapidly and reversibly perturb the functions of specific proteins are desirable tools for studies of complex biological processes. We have demonstrated an experimental strategy to regulate the intracellular concentration of any protein of interest by using an engineered destabilizing protein domain and a cell-permeable small molecule. Destabilizing domains have general utility to confer instability to...

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Identifiers

PMID: 22332638
DOI: 10.1021/ja209933r
PMCID: PMC3296833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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