Article
A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 2008
Paulmurugan Ramasamy, Tamrazi Anobel, Katzenellenbogen John A, Katzenellenbogen Benita S, Gambhir Sanjiv S
Abstract excerpt
Estrogens, acting through the estrogen receptors (ERs), play crucial roles in regulating the function of reproductive and other systems under physiological and pathological conditions. ER activity in regulating target genes is modulated by the binding of both steroidal and synthetic nonsteroidal ligands, with ligand binding inducing ERs to adopt various conformations that control their interactions with...
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