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Article

Treatment-related mutagenic processes in acute lymphoblastic leukemia.

Haematologica - 1 Oct 2025

Van der Ham Cédric G, Van Leeuwen Frank N, Kuiper Roland P

Abstract excerpt

Karyotyping, SNP arrays, fluorescence in situ hybridization and next-generation sequencing techniques have greatly improved our understanding of the genetic drivers of acute lymphoblastic leukemia (ALL). In the past years, another layer of genetic data has been added by the study of mutational signatures, patterns of somatic mutations that represent specific mutational mechanisms. Mutational signatures can give...

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Topics

Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mutation
DNA Damage
Mutagenesis
Drug Resistance, Neoplasm

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Identifiers

PMID: 40371888
DOI: 10.3324/haematol.2025.287774
PMCID: PMC12485317

Genes

TP53

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