Article
Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2007
Thananchai Hathairat, Gillespie Geraldine, Martin Maureen P, Bashirova Arman, Yawata Nobuyo, Yawata Makoto, Easterbrook Philippa, McVicar Daniel W, Maenaka Katsumi, Parham Peter, Carrington Mary, Dong Tao, Rowland-Jones Sarah
Abstract excerpt
Although it is clear that KIR3DL1 recognizes Bw4(+) HLA-B, the role of Bw4(+) HLA-A allotypes as KIR3DL1 ligands is controversial. We therefore examined the binding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4(+) HLA-A allotype, to KIR3DL1*001, *005, *007, and *1502 allotypes. Only Bw4(+) tetramers bound KIR3DL1. Three of four HLA-A*2402 tetramers bound one or more KIR3DL1 allotypes and...
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