Article
The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2015
Saunders Philippa M, Vivian Julian P, Baschuk Nikola, Beddoe Travis, Widjaja Jacqueline, O'Connor Geraldine M, Hitchen Corinne, Pymm Phillip, Andrews Daniel M, Gras Stephanie, McVicar Daniel W, Rossjohn Jamie, Brooks Andrew G
Abstract excerpt
The killer cell Ig-like receptor 3DL1 (KIR3DL1) inhibits activation of NK cells upon interaction with HLA class I molecules such as HLA-B*57:01, which contains the Bw4 epitope spanning residues 77-83 (e.g., NLRIALR), and not with HLA allomorphs that possess the Bw6 motif (e.g., HLA-B*08:01), which differ at residues 77, 80, 81, 82, and 83. Although Bw4 residues Ile(80) and Arg(83) directly interact with...
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