Article

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells

2022-08-18

Abstract excerpt

Most human killer cell immunoglobulin-like receptors (KIR) are expressed by Natural Killer (NK) cells and recognize HLA class I molecules as ligands. Uniquely, KIR3DL3 is a conserved but polymorphic inhibitory KIR recognizing a B7 family ligand, HHLA2, and is implicated for immune checkpoint targeting. Because the expression profile and biological function of KIR3DL3 remained elusive, we searched extensively for K...

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Literature Corpus work: 8bb1738a-0deb-5647-a6be-77c11bddfb8b
DOI: 10.1101/2022.08.17.503789

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