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Article

KIR3DS1-Specific D0 Domain Polymorphisms Disrupt KIR3DL1 Surface Expression and HLA Binding.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2015

Mulrooney Tiernan J, Zhang Aaron C, Goldgur Yehuda, Boudreau Jeanette E, Hsu Katharine C

Abstract excerpt

KIR3DL1 is a polymorphic inhibitory receptor that modulates NK cell activity through interacting with HLA-A and HLA-B alleles that carry the Bw4 epitope. Amino acid polymorphisms throughout KIR3DL1 impact receptor surface expression and affinity for HLA. KIR3DL1/S1 encodes inhibitory and activating alleles, but despite high homology with KIR3DL1, the activating receptor KIR3DS1 does not bind the same ligand....

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Source

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Identifiers

PMID: 26109640
DOI: 10.4049/jimmunol.1500243
PMCID: PMC4506867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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KIR3DS1-Specific D0 Domain Polymorphisms Disrupt KIR3DL1 Surface Expression and HLA Binding.PMID 26109640Read ↗

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