Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.

doi:10.1038/ng2111

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Article

Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.

Nature genetics - 1 Sept 2007

Norman Paul J, Abi-Rached Laurent, Gendzekhadze Ketevan, Korbel Daniel, Gleimer Michael, Rowley Don, Bruno Dan, Carrington Christine V F, Chandanayingyong Dasdayanee, Chang Yih-Hsin, Crespí Catalina, Saruhan-Direskeneli Güher, Fraser Patricia A, Hameed Kamran, Kamkamidze Giorgi, Koram Kwadwo A, Layrisse Zulay, Matamoros Nuria, Milà Joan, Park Myoung Hee, Pitchappan Ramasamy M, Ramdath D Dan, Shiau Ming-Yuh, Stephens Henry A F, Struik Siske, Verity David H, Vaughan Robert W, Tyan Dolly, Davis Ronald W, Riley Eleanor M, Ronaghi Mostafa, Parham Peter

Abstract excerpt

Interactions of killer cell immunoglobulin-like receptors (KIRs) with major histocompatibility complex (MHC) class I ligands diversify natural killer cell responses to infection. By analyzing sequence variation in diverse human populations, we show that the KIR3DL1/S1 locus encodes two lineages of polymorphic inhibitory KIR3DL1 allotypes that recognize Bw4 epitopes of protein">HLA-A and HLA-B and one lineage of...

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PMID: 17694054
DOI: 10.1038/ng2111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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