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Article

Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 molecules.

Journal of virology - 1 Jun 2011

Fadda Lena, O'Connor Geraldine M, Kumar Swati, Piechocka-Trocha Alicja, Gardiner Clair M, Carrington Mary, McVicar Daniel W, Altfeld Marcus

Abstract excerpt

Epidemiological studies have shown the protective effect of KIR3DL1/HLA-Bw4 genotypes in human immunodeficiency virus type 1 (HIV-1) infection; however, the functional correlates for the protective effect remain unknown. We investigated whether human leukocyte antigen (HLA)-Bw4-presented HIV-1 peptides could affect the interaction between the inhibitory natural killer (NK) cell receptor KIR3DL1 and its ligand...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21471246
DOI: 10.1128/JVI.00412-11
PMCID: PMC3126328

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Common HIV-1 peptide variants mediate differential binding of KIR3DL1 to HLA-Bw4 molecules.PMID 21471246Read ↗

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