Article
KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.
PLoS pathogens - 1 Mar 2011
Colantonio Arnaud D, Bimber Benjamin N, Neidermyer William J, Reeves R Keith, Alter Galit, Altfeld Marcus, Johnson R Paul, Carrington Mary, O'Connor David H, Evans David T
Abstract excerpt
Molecular interactions between killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands play a central role in the regulation of natural killer (NK) cell responses to viral pathogens and tumors. Here we identify Mamu-A1*00201 (Mamu-A*02), a common MHC class I molecule in the rhesus macaque with a canonical Bw6 motif, as a ligand for Mamu-KIR3DL05. Mamu-A1*00201 tetramers folded with certain SIV...
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