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Article

Development of a novel multiplex PCR assay to detect functional subtypes of KIR3DL1 alleles.

PloS one - 1 Jan 2014

Boudreau Jeanette E, Le Luduec Jean-Benoît, Hsu Katharine C

Abstract excerpt

Among NK cell receptor-ligand partnerships, KIR3DL1 and HLA-Bw4 demonstrate the greatest diversity; permutations of their allelic combinations titrate NK reactivity. Balancing selection has maintained distinct subtypes of KIR3DL1 alleles in global populations, implying that each may provide unique fitness advantages and variably influence disease processes. Though approaches exist for determining HLA-B allotypes,...

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Share to Alleles
Share to Killer Cells, Natural
Share to Multiplex Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, KIR3DL1

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Identifiers

PMID: 24919192
DOI: 10.1371/journal.pone.0099543
PMCID: PMC4053526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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