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Article

Catechol-O-methyltransferase Val158Met polymorphism on the relationship between white matter hyperintensity and cognition in healthy people.

PloS one - 1 Jan 2014

Liu Mu-En, Huang Chu-Chung, Yang Albert C, Tu Pei-Chi, Yeh Heng-Liang, Hong Chen-Jee, Liou Ying-Jay, Chen Jin-Fan, Chou Kun-Hsien, Lin Ching-Po, Tsai Shih-Jen

Abstract excerpt

BACKGROUND: White matter lesions can be easily observed on T2-weighted MR images, and are termed white matter hyperintensities (WMH). Their presence may be correlated with cognitive impairment; however, the relationship between regional WMH volume and catechol-O-methyltransferase (COMT) Val158Met polymorphism in healthy populations remains unclear. METHODS: We recruited 315 ethnic Chinese adults with a mean age...

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Identifiers

PMID: 24551149
DOI: 10.1371/journal.pone.0088749
PMCID: PMC3923794

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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