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Article

Catechol-o-methyl transferase modulates cognition in late life: evidence and implications for cognitive enhancement.

CNS & neurological disorders drug targets - 1 May 2012

Sambataro Fabio, Pennuto Maria, Christian Wolf Robert

Abstract excerpt

Aging is associated with deficits in several cognitive domains as well as a decline in brain dopamine activity. Catechol-O-methyl transferase (COMT), an enzyme involved in the degradation of dopamine, is a critical determinant of the availability of this neurotransmitter in the prefrontal cortex. A functional single nucleotide polymorphism in the COMT gene, Val158Met, modulates the activity of this enzyme and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22483295
DOI: 10.2174/187152712800672463

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Catechol-o-methyl transferase modulates cognition in late life: evidence and implications for cognitive enhancement.PMID 22483295Read ↗

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