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Article

Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia.

Neuroscience letters - 9 May 2008

Liu Mu-En, Hong Chen-Jee, Liou Ying-Jay, Tsai Yung-Lang, Hsieh Cheng-Hsi, Tsai Shih-Jen

Abstract excerpt

Cognitive function in older people is a major factor influencing quality of life. The catechol-O-methyltransferase (COMT) gene, which is essential in the metabolic degradation of prefrontal dopamine, has been considered as a leading candidate gene in the variation in cognitive performance. The aim of this study was to investigate the effect of a functional COMT (Val158Met) polymorphism on several cognition...

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Source

Identifiers

PMID: 18387741
DOI: 10.1016/j.neulet.2008.03.018

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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