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Article

Catechol-O-methyltransferase Val158Met polymorphism modulates gray matter volume and functional connectivity of the default mode network.

PloS one - 1 Jan 2013

Tian Tian, Qin Wen, Liu Bing, Wang Dawei, Wang Junping, Jiang Tianzi, Yu Chunshui

Abstract excerpt

The effect of catechol-O-methyltransferase (COMT) Val158Met polymorphism on brain structure and function has been previously investigated separately and regionally; this prevents us from obtaining a full picture of the effect of this gene variant. Additionally, gender difference must not be overlooked because estrogen exerts an interfering effect on COMT activity. We examined 323 young healthy Chinese Han...

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Identifiers

PMID: 24147141
DOI: 10.1371/journal.pone.0078697
PMCID: PMC3797700

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Catechol-O-methyltransferase Val158Met polymorphism modulates gray matter volume and functional connectivity of the default mode network.PMID 24147141Read ↗

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