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Article

Differential effects of the catechol-O-methyltransferase Val158Met genotype on the cognitive function of schizophrenia patients and healthy Japanese individuals.

PloS one - 1 Jan 2013

Tsuchimine Shoko, Yasui-Furukori Norio, Kaneda Ayako, Kaneko Sunao

Abstract excerpt

BACKGROUND: The functional polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene has been associated with differences in prefrontal cognitive functions in patients with schizophrenia and healthy individuals. Several studies have indicated that the Met allele is associated with better performance on measures of cognitive function. We investigated whether the COMT Val158Met genotype was associated...

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Identifiers

PMID: 24282499
DOI: 10.1371/journal.pone.0076763
PMCID: PMC3839926

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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