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Article

Effects of COMT polymorphisms on brain function and behavior in health and disease.

Brain research bulletin - 1 Aug 2012

Witte A Veronica, Flöel Agnes

Abstract excerpt

The catechol-O-methyltransferase (COMT) gene has attracted strong neuroscientific interest due to its implication in dopaminergic neurotransmission. One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in...

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Source

Identifiers

PMID: 22138198
DOI: 10.1016/j.brainresbull.2011.11.012

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effects of COMT polymorphisms on brain function and behavior in health and disease.PMID 22138198Read ↗

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Gender effects of the COMT Val 158 Met genotype on verbal fluency in healthy adults.Semantic proximity Read ↗

Met158 variant of the catechol-O-methyltransferase genotype is associated with thicker cortex in adult brain.Semantic proximity Read ↗

The COMT val158met polymorphism and brain morphometry in healthy young adults.Semantic proximity Read ↗

Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.Semantic proximity Read ↗

The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes.Semantic proximity Read ↗

The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.Semantic proximity Read ↗

Influence of the COMT genotype on working memory and brain activity changes during development.Semantic proximity Read ↗

Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects.Semantic proximity Read ↗

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