Article
COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.
Genes, brain, and behavior - 1 Apr 2013
Wang Y, Li J, Chen C, Chen C, Zhu B, Moysis R K, Lei X, Li H, Liu Q, Xiu D, Liu B, Chen W, Xue G, Dong Q
Abstract excerpt
Catechol-O-methyltransferase (COMT) Val158Met (rs4680) polymorphism plays a crucial role in regulating brain dopamine level. Converging evidence from Caucasian samples showed that, compared with rs4680 Val allele, the Met allele was linked to lower COMT activity, which in turn was linked to better cognitive performance such as working memory (WM) and to a larger hippocampus (a brain region important for WM)....
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