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Article

COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults.

Journal of the International Neuropsychological Society : JINS - 1 Jan 2011

Wishart Heather A, Roth Robert M, Saykin Andrew J, Rhodes C Harker, Tsongalis Gregory J, Pattin Kristine A, Moore Jason H, McAllister Thomas W

Abstract excerpt

The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene may be related to individual differences in cognition, likely via modulation of prefrontal dopamine catabolism. However, the available studies have yielded mixed results, possibly in part because they do not consistently account for other genes that affect cognition. We hypothesized that COMT Met allele homozygosity, which is associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21144101
DOI: 10.1017/S1355617710001402
PMCID: PMC3114452

Genes

COMT
APOE
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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