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Article

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption

1 Jan 2014

Abstract excerpt

The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. The habenulo-interpeduncular (Hb-IPN) tract is particularly enriched in α3β4 nAChRs. We recently showed that modulation of these receptors in the medial habenula (MHb) in mice altered nicotine consumption. Given that β4 is rate-limiting for receptor activity...

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Identifiers

PMID: 24478678
DOI: 10.3389/fnhum.2014.00012

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