Article
Rare coding variants in CHRNB2 reduce the likelihood of smoking.
Nature genetics - 1 Jul 2023
Rajagopal Veera M, Watanabe Kyoko, Mbatchou Joelle, Ayer Ariane, Quon Peter, Sharma Deepika, Kessler Michael D, Praveen Kavita, Gelfman Sahar, Parikshak Neelroop, Otto Jacqueline M, Bao Suying, Chim Shek Man, Pavlopoulos Elias, Avbersek Andreja, Kapoor Manav, Chen Esteban, Jones Marcus B, Leblanc Michelle, Emberson Jonathan, Collins Rory, Torres Jason, Morales Pablo Kuri, Tapia-Conyer Roberto, Alegre Jesus, Berumen Jaime, Shuldiner Alan R, Balasubramanian Suganthi, Abecasis Gonçalo R, Kang Hyun M, Marchini Jonathan, Stahl Eli A, Jorgenson Eric, Sanchez Robert, Liedtke Wolfgang, Anderson Matthew, Cantor Michael, Lederer David, Baras Aris, Coppola Giovanni
Abstract excerpt
Human genetic studies of smoking behavior have been thus far largely limited to common variants. Studying rare coding variants has the potential to identify drug targets. We performed an exome-wide association study of smoking phenotypes in up to 749,459 individuals and discovered a protective association in CHRNB2, encoding the β2 subunit of the α4β2 nicotine acetylcholine receptor. Rare predicted...
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