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Article

α3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Feb 2021

Elayouby Karim S, Ishikawa Masago, Dukes Angeline J, Smith Alexander C W, Lu Qun, Fowler Christie D, Kenny Paul J

Abstract excerpt

Allelic variation in CHRNA3, the gene encoding the α3 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and smoking-related diseases, but little is known about the role for α3-containing (α3*) nAChRs in regulating the addiction-related behavioral or physiological actions of nicotine. α3* nAChRs are densely expressed by medial habenula (mHb) neurons, which project...

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Identifiers

PMID: 33380469
DOI: 10.1523/JNEUROSCI.0127-19.2020
PMCID: PMC8115890

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