Article
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.
Neuron - 12 May 2011
Frahm Silke, Slimak Marta A, Ferrarese Leiron, Santos-Torres Julio, Antolin-Fontes Beatriz, Auer Sebastian, Filkin Sergey, Pons Stéphanie, Fontaine Jean-Fred, Tsetlin Victor, Maskos Uwe, Ibañez-Tallon Inés
Abstract excerpt
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR). Here we show that the β4 subunit is rate limiting for receptor activity, and that current increase by β4 is maximally competed by one of the most frequent variants associated with tobacco usage (D398N in α5). We identify a β4-specific residue...
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