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Article

PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2014

Maine Christian J, Marquardt Kristi, Cheung Jocelyn, Sherman Linda A

Abstract excerpt

A single nucleotide polymorphism in PTPN22 (R620W), which encodes the Lyp tyrosine phosphatase, has been linked to a number of autoimmune diseases including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Studies in PTPN22 knockout (KO) mice and in mice expressing the mouse homolog of the pro-autoimmune allele, PEP(R619W), have reported increased germinal center activity and enhanced Ab...

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Source

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Identifiers

PMID: 24453256
DOI: 10.4049/jimmunol.1302418
PMCID: PMC3933017

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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