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Article

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

FEBS letters - 1 Dec 2011

Burn Garth L, Svensson Lena, Sanchez-Blanco Cristina, Saini Manoj, Cope Andrew P

Abstract excerpt

The PTPN22 locus is one of the strongest risk factors outside of the major histocompatability complex that associates with autoimmune diseases. PTPN22 encodes lymphoid protein tyrosine phosphatase (Lyp) which is expressed exclusively in immune cells. A single base change in the coding region of this gene resulting in an arginine to tryptophan amino acid substitution within a polyproline binding motif associates...

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Source

Identifiers

PMID: 21515266
DOI: 10.1016/j.febslet.2011.04.032

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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