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Article

Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice.

Endocrine - 1 Mar 2020

Shi Xiajie, Shao Feng, Li Zhixia, Kang Lin, Liu Junbin, Kissler Stephan, Zhou Zhiguang, Jia Lijing, Zheng Peilin

Abstract excerpt

PURPOSE: A coding variant in PTPN22 (C1858T) is one of the most important genetic risk factors in type 1 diabetes (T1D). The role of the PTPN22 risk allele in B cells is still incompletely understood and has not been investigated directly in T1D. This study aimed to explore the role of PTPN22 in the homeostasis of B cells and its influence in T1D. METHODS: Wild-type (WT) and Ptpn22 inducible knockdown (KD) NOD...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred NOD

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Identifiers

PMID: 31732921
DOI: 10.1007/s12020-019-02120-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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