Article
Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.
Science signaling - 27 Nov 2012
Brownlie Rebecca J, Miosge Lisa A, Vassilakos Demetrios, Svensson Lena M, Cope Andrew, Zamoyska Rose
Abstract excerpt
The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key role in regulating lymphocyte homeostasis, which ensures that the total number of lymphocytes in the periphery remains relatively constant. Mutations in PTPN22 confer an increased risk of developing autoimmune diseases; however, the precise function of PTPN22 and how mutations contribute to autoimmunity remain...
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