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Article

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

The Journal of clinical investigation - 1 May 2013

Dai Xuezhi, James Richard G, Habib Tania, Singh Swati, Jackson Shaun, Khim Socheath, Moon Randall T, Liggitt Denny, Wolf-Yadlin Alejandro, Buckner Jane H, Rawlings David J

Abstract excerpt

Multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, Graves disease, and systemic lupus erythematosus, are associated with an allelic variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22), which encodes the protein LYP. To model the human disease-linked variant LYP-R620W, we generated knockin mice expressing the analogous mutation, R619W, in the murine ortholog PEST domain...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23619366
DOI: 10.1172/JCI66963
PMCID: PMC3638909

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.PMID 23619366Read ↗

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