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Article

Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.

Journal of biochemistry - 1 Apr 2014

Nakanaga Keita, Hama Kotaro, Kano Kuniyuki, Sato Takanao, Yukiura Hiroshi, Inoue Asuka, Saigusa Daisuke, Tokuyama Hidetoshi, Tomioka Yoshihisa, Nishina Hiroshi, Kawahara Atsuo, Aoki Junken

Abstract excerpt

Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are second-generation lysophospholipid mediators that exert multiple biological functions through their own cognate receptors. They are both present in the blood stream, activate receptors with similar structures (endothelial differentiation gene receptors), have similar roles in the vasculature and are vasoactive. However, it is unclear whether these...

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Share to Embryo, Nonmammalian
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24451492
DOI: 10.1093/jb/mvt114

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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