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Article

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.

The Journal of biological chemistry - 25 Jan 2013

Mendelson Karen, Zygmunt Tomasz, Torres-Vázquez Jesús, Evans Todd, Hla Timothy

Abstract excerpt

Sphingosine 1-phosphate (S1P) binds G-protein-coupled receptors (S1P(1-5)) to regulate a multitude of physiological effects, especially those in the vascular and immune systems. S1P receptors in the vascular system have been characterized primarily in mammals. Here, we report that the S1P receptors and metabolic enzymes are conserved in the genome of zebrafish Danio rerio. Bioinformatic analysis identified seven...

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Identifiers

PMID: 23229546
DOI: 10.1074/jbc.M112.427344
PMCID: PMC3554887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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