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Article

Maternal and Zygotic Sphingosine Kinase 2 Are Indispensable for Cardiac Development in Zebrafish.

The Journal of biological chemistry - 12 Jun 2015

Hisano Yu, Inoue Asuka, Okudaira Michiyo, Taimatsu Kiyohito, Matsumoto Hirotaka, Kotani Hirohito, Ohga Rie, Aoki Junken, Kawahara Atsuo

Abstract excerpt

Sphingosine 1-phosphate (S1P) is synthesized from sphingosine by sphingosine kinases (SPHK1 and SPHK2) in invertebrates and vertebrates, whereas specific receptors for S1P (S1PRs) selectively appear in vertebrates, suggesting that S1P acquires novel functions in vertebrates. Because the developmental functions of SPHK1 and SPHK2 remain obscure in vertebrates, we generated sphk1 or sphk2 gene-disrupted zebrafish...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25907554
DOI: 10.1074/jbc.M114.634717
PMCID: PMC4463432

Genes

SPHK1
SPHK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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