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Article

The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.

Science (New York, N.Y.) - 23 Jan 2009

Kawahara Atsuo, Nishi Tsuyoshi, Hisano Yu, Fukui Hajime, Yamaguchi Akihito, Mochizuki Naoki

Abstract excerpt

Sphingosine-1-phosphate (S1P) is a secreted lipid mediator that functions in vascular development; however, it remains unclear how S1P secretion is regulated during embryogenesis. We identified a zebrafish mutant, ko157, that displays cardia bifida (two hearts) resembling that in the S1P receptor-2 mutant. A migration defect of myocardial precursors in the ko157 mutant is due to a mutation in a multipass...

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Identifiers

PMID: 19074308
DOI: 10.1126/science.1167449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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