Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

doi:10.1016/j.cell.2013.10.058

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Article

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

Cell - 16 Jan 2014

Claussnitzer Melina, Dankel Simon N, Klocke Bernward, Grallert Harald, Glunk Viktoria, Berulava Tea, Lee Heekyoung, Oskolkov Nikolay, Fadista Joao, Ehlers Kerstin, Wahl Simone, Hoffmann Christoph, Qian Kun, Rönn Tina, Riess Helene, Müller-Nurasyid Martina, Bretschneider Nancy, Schroeder Timm, Skurk Thomas, Horsthemke Bernhard, Spieler Derek, Klingenspor Martin, Seifert Martin, Kern Michael J, Mejhert Niklas, Dahlman Ingrid, Hansson Ola, Hauck Stefanie M, Blüher Matthias, Arner Peter, Groop Leif, Illig Thomas, Suhre Karsten, Hsu Yi-Hsiang, Mellgren Gunnar, Hauner Hans, Laumen Helmut

Abstract excerpt

Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility. We show that integrative computational analysis of phylogenetic conservation with a complexity...

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PMID: 24439387
DOI: 10.1016/j.cell.2013.10.058
PMCID: PMC7116609

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PRRX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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