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Article

Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery.

Molecular biology and evolution - 1 Sept 2012

Dudley Joel T, Chen Rong, Sanderford Maxwell, Butte Atul J, Kumar Sudhir

Abstract excerpt

Genome-wide disease association studies contrast genetic variation between disease cohorts and healthy populations to discover single nucleotide polymorphisms (SNPs) and other genetic markers revealing underlying genetic architectures of human diseases. Despite scores of efforts over the past decade, many reproducible genetic variants that explain substantial proportions of the heritable risk of common human...

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Identifiers

PMID: 22389448
DOI: 10.1093/molbev/mss079
PMCID: PMC3424407

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