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Article

Characterizing genetic variation in the regulation of the ER stress response through computational and cis-eQTL analyses.

G3 (Bethesda, Md.) - 6 Dec 2023

Russell Nikki D, Jorde Lynn B, Chow Clement Y

Abstract excerpt

Misfolded proteins in the endoplasmic reticulum (ER) elicit the ER stress response, a large transcriptional response driven by 3 well-characterized transcription factors (TFs). This transcriptional response is variable across different genetic backgrounds. One mechanism in which genetic variation can lead to transcriptional variability in the ER stress response is through altered binding and activity of the 3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37792690
DOI: 10.1093/g3journal/jkad229
PMCID: PMC10700025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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