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Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity

1 Nov 2019

Abstract excerpt

Obesity is a clinical problem and an important adaptation in many species. Hibernating mammals, for example, become obese, insulin resistant, and hyperinsulinemic to store fat. Here, we combine comparative phylogenomics with large-scale human genome data to uncover candidate cis elements regulating mammalian obesity. Our study examines genetic elements conserved across non-hibernating mammals to identify...

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PMID: 31775032
DOI: 10.1016/j.celrep.2019.10.102

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