Article
Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways.
eLife - 3 Oct 2014
Ballester Benoit, Medina-Rivera Alejandra, Schmidt Dominic, Gonzàlez-Porta Mar, Carlucci Matthew, Chen Xiaoting, Chessman Kyle, Faure Andre J, Funnell Alister P W, Goncalves Angela, Kutter Claudia, Lukk Margus, Menon Suraj, McLaren William M, Stefflova Klara, Watt Stephen, Weirauch Matthew T, Crossley Merlin, Marioni John C, Odom Duncan T, Flicek Paul, Wilson Michael D
Abstract excerpt
As exome sequencing gives way to genome sequencing, the need to interpret the function of regulatory DNA becomes increasingly important. To test whether evolutionary conservation of cis-regulatory modules (CRMs) gives insight into human gene regulation, we determined transcription factor (TF) binding locations of four liver-essential TFs in liver tissue from human, macaque, mouse, rat, and dog. Approximately, two...
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