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Article

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing.

Nature communications - 1 Jan 2014

Adachi Kei, Enoki Tatsuji, Kawano Yasuhiro, Veraz Michael, Nakai Hiroyuki

Abstract excerpt

Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed AAV Barcode-Seq, that allows us to characterize phenotypes of hundreds of different AAV strains in a high-throughput...

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Share to Capsid
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Share to DNA Barcoding, Taxonomic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24435020
DOI: 10.1038/ncomms4075
PMCID: PMC3941020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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