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Article

A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism

9 Dec 2019

Abstract excerpt

Adeno-associated virus (AAV) capsid modification enables the generation of recombinant vectors with tailored properties and tropism. Most approaches to date depend on random screening, enrichment, and serendipity. The approach explored here, called BRAVE (barcoded rational AAV vector evolution), enables efficient selection of engineered capsid structures on a large scale using only a single screening round in...

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PMID: 31818949
DOI: 10.1073/pnas.1910061116

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